5 edition of The Ubiquitous Roles of Cytochrome P450 Proteins found in the catalog.
June 4, 2007
Written in English
|Contributions||Astrid Sigel (Editor), Helmut Sigel (Editor), Roland K. O. Sigel (Editor)|
|The Physical Object|
|Number of Pages||678|
The Cytochrome Ps are among nature's most versatile and ubiquitous enzymes because of their extraordinary ability to perform highly regio- and stereo-selective oxidation reactions on a wide variety of compounds including alkanes, fatty acids, terpenes, steroids, detoxification of carcinogens, pesticides and other pharmaceuticals [,,, ].Using molecular oxygen and reducing equivalents. Lo J, Di Nardo G, Griswold J, Egbuta C, Jiang W, Gilardi G, Ghosh D. Structural basis for the functional roles of critical residues in human cytochrome p aromatase. Biochemistry. ;–9. CrossRef PubMedCentral PubMed Google ScholarCited by: 1.
Cytochrome P 2D6 is a unique, valuable book focusing on a single but immensely powerful human gene. It provides the first single source of comprehensive information on CYP2D6 that serves as an important reference for medical, biomedical, pharmaceutical, and . Cytochrome P (CYP) 1 enzymes are heme-dependent monooxygenases that catalyze the insertion of an oxygen atom from atmospheric dioxygen into carbon–hydrogen bonds in a diverse range of organic compounds,. They have many physiological roles including hormone and secondary metabolite biosynthesis, as well as xenobiotic by:
Introduction. The human cytochrome P (CYP) family comprises 57 isozymes in humans. These enzymes function in normal metabolism, influencing drug pharmacokinetics, and effect negative outcomes in patients through drug-drug interactions (DDIs).1, 2 The CYP isozymes metabolize approximately two-thirds of known drugs in humans, with 80% of this attributable to five isozymes - Cited by: 1. Introduction. Cytochrome P (CYP) superfamily enzymes are broadly involved in a variety of physiological and toxicological processes, such as metabolism of endogenous and exogenous molecules, and host defense responses [1,2,3,4].Therefore, CYPs are of particular relevance for clinical pharmacology and are of interest to many by: 1.
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"Cytochrome P aficionados will not want to be without either of these two books." (Journal of the American Chemical Society, Decem ) "This is a well produced and comprehensive effort." (Doody's Health Services).
11 CYTOCHROME PCATALYZED HYDROXYLATIONS AND EPOXIDATIONS Roshan Perera, Shengxi Jin, Masanori Sono, and John H. Dawson 1. Introduction 2. The Cytochrome P Enzymes 3.
Three-Dimensional Structures of the Active Sites of Cytochrome P Enzymes 4. Role of the Cys Ligand: the Proximal Thiolate ‘Push’ and Distal Proton-Delivery 5.
The Ubiquitous Roles of Cytochrome P Proteins, Volume 3 Astrid Sigel (Editor), Helmut Sigel (Co-Editor), Roland K. Sigel (Co-Editor) ISBN: April Pages. The Ubiquitous Roles of Cytochrome P Proteins (Metal Ions in Life Sciences, Volume 3) Astrid Sigel, Helmut Sigel, Roland K.O.
Sigel Helmut Sigel, Astrid Sigel and Roland K.O. Sigel, in close cooperation with John Wiley & Sons launch a new Series “Metal Ions in Life Sciences”.There exists a whole range of books on Cytochromes P, but none with the focus of this volume.
The ubiquitous roles of cytochrome P proteins. [Astrid Sigel; Helmut Sigel; Roland K O Sigel;] -- The book highlights, supported by nearly references, more than 20 tables and illustrations, the function of these versatile catalysts which act as monooxygenases and insert an oxygen atom.
Book Editor(s): Astrid Sigel. Department of Chemistry, Inorganic Chemistry, University of Basel, Spitalstra CH‐ Basel, Switzerland The Ubiquitous Roles of Cytochrome P Proteins, Volume 3. Related; Information; Close Figure Viewer. Browse All Figures Return to Figure. Previous Figure Next Figure.
Caption. Additional links Cited by: 2. The Ubiquitous Roles of Cytochrome P Proteins highlights, supported by nearly references, more than 20 tables and illustrations, the function of these versatile catalysts which act as monooxygenases and insert an oxygen atom from dioxygen into a substrate molecule oxidizing by: Summary This chapter contains sections titled: Introduction Catalytic Cycles Electron Tunneling Wires Concluding Remarks Acknowledgments Abbreviations References P Electron Transfer Reactions - The Ubiquitous Roles of Cytochrome P Proteins - Wiley Online LibraryCited by: 3.
Cytochromes P – Structural Basis for Binding and Catalysis. Konstanze von König. Book Editor(s): Astrid Sigel. The Ubiquitous Roles of Cytochrome P Proteins, Volume 3. Related; Information; Close Figure Viewer.
Browse All Figures Return to by: 5. Cytochrome P is a super-family of enzymes and mainly responsible for catalyzing the metabolism of many drugs. The CYP 1A subfamily mainly participates in the metabolism of aromatic compounds, while the CYP 3A subfamily metabolizes most of the therapeutic drugs (Tsuji Cited by: 6.
Request PDF | The Ubiquitous Roles of Cytochrome P Proteins, Volume 3 | IntroductionCatalytic CyclesElectron Tunneling WiresConcluding. The cytochrome P (CYP) is a large superfamily of integral membrane conserved proteins present in animals, plants, and microorganisms (Nebert and Russell, ).
The CYP isoenzyme superfamily comprises 57 CYP genes and 58 pseudogenes arranged into 18 families and 43 subfamilies in man (Nelson et al., ).Cited by: Contribution to Book P Electron Transfer Reactions. The Ubiquitous Roles of Cytochrome P Proteins: Metal Ions in Life Sciences () Andrew K Udit, Stephen M Contakes and Harry B.
Gray. "P Electron Transfer Reactions" The Ubiquitous Roles of Cytochrome P Proteins: Metal Ions in Life Sciences Vol. 3 () p. - Cited by: 3. The Ubiquitous Roles of Cytochrome P Proteins highlights, supported by nearly references, more than 20 tables and illustrations, the function of these versatile catalysts which act as monooxygenases and insert an oxygen atom from dioxygen into a substrate molecule oxidizing it.
Buy the Hardcover Book The Ubiquitous Roles of Cytochrome P Proteins: Metal Ions in Life Sciences by Astrid Sigel atCanada's largest bookstore.
Free. The Ubiquitous Roles of Cytochrome P Proteins Metal Ions in Life Sciences There exists a whole range of books on Cytochromes P, but none with the focus of this volume. This new volume in the Series concentrates on current hot topics in the area and tries to work out the underlying common developments.
The Ubiquitous Roles of. Cytochrome P reductase is a ubiquitous microsomal electron transfer protein most often associated with drug and xenobiotic metabolism, but its role in cellular biochemistry is much larger than that (summarized in Fig.
POR is essential to steroid hormone synthesis, cholesterol homeostasis through bile acid synthesis, heme catabolism, and perhaps most importantly, cholesterol by: Protein–protein interactions are essential to the function of the ubiquitous xenobiotic-metabolizing cytochrome P monooxygenases, or CYPs.
1 Classic studies have demonstrated the importance of CYP interactions with the accessory proteins cytochrome P reductase (CPR) and cytochrome b5 (b5) for both electron transfer and allosteric modulation.
2−4 However, it has recently become clear that CYP enzymes may participate in additional interactions with other protein partners Cited by: Front Matter --Diversities and Similarities in P Systems: An Introduction / Mary A Schuler, Stephen G Sligar --Structural and Functional Mimics of Cytochromes P / Wolf-D Woggon --Structures of P Proteins and Their Molecular Phylogeny / Thomas L Poulos, Yergalem T Meharenna --Aquatic P Species / Mark J Snyder --The Electrochemistry.
The cytochrome P (CYP) superfamily is the largest enzymatic protein family in plants, and it also widely exists in mammals, fungi, bacteria, insects and so on. Members of this superfamily are involved in multiple metabolic pathways with distinct and complex functions, playing important roles Cited by:.
Nevertheless, chemical probes have been widely used to study the structure and function of cytochromes P as well as functionally linked protein-protein interactions in cytochrome P systems.Find in a Library Find The Ubiquitous Roles of Cytochrome P Proteins near you.
Some cytochrome P (CYP) enzymes participate in the detoxication of xenobiotics and, paradoxically, can form reactive intermediates that can damage DNA, lipids and proteins Cited by: